Institute of Pharmaceutical Sciences, SAGE University, Indore (M.P.)
The pharmacokinetic profile, tissue targeting, and localized medication delivery of synthetic and herbal medicines can all be improved by liposomes, a sophisticated drug delivery method. The structure, classification, preparation techniques, and therapeutic uses of liposomes are examined in this paper, with an emphasis on how they may be used to treat acne vulgaris, a prevalent dermatological ailment. Liposomes are perfect for topical treatments because of their capacity
to encapsulate hydrophilic and lipophilic medications, enhance drug absorption through the skin, and reduce systemic adverse effects. Herbal extracts like neem, aloe vera, and green tea can be added to liposomal formulations to provide antioxidant effects and lessen the irritation that synthetic medications cause. Various types of liposomes, including multilamellar and uni-lamellar vesicles, are discussed alongside methods for their preparation, such as lipid hydration and solvent injection techniques. Furthermore, the development and evaluation of liposomal gels are addressed through parameters like pH, viscosity, spreadability, skin irritation, and in vitro drug diffusion. Stability studies confirm the potential of liposomal formulations for sustained and targeted dermal drug delivery. This review highlights liposomes as promising carriers for the effective and safer treatment of acne vulgaris.